Genomic Instability: DNA Repair and CancerThis chapter explores how genomic instability can be generated and how this can impact in cancer. We start this chapter by summarizing key concepts, in particular genomic instability and DNA repair, which are the foundations to understand the remaining chapter. Next, we highlight the role of central proteins in the DNA damage response, such as the DNA damage signaling kinases ATM and ATR, and the tumor suppressor protein p53, known as the “guardian of the genome”.
